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Plain English summary of "The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients"

Published in Oncotarget, January 2015

In this study the DNA from tumor samples from 10 patients was sequenced and compared to the DNA from non-cancerous tissue from the same patient to identify mutations that had occurred in the cancer. The only consistent mutation in patients was the DNAJB1-PRKACA deletion. Other mutated genes that were found in more than one patient included MUC4, GOLGA6L2, DSPP, FOXO6 and HLA-DRB1, gene which have been implicated in other types of cancer. Since the only consistent mutation found was the DNAJB1-PRKACA deletion, this mutation may be sufficient to cause the cancer, and research into the fusion protein produced by the mutation probably offers the best chances of improving the diagnostic and treatment option for fibrolamellar patients. As compared to other cancers, fibrolamellar seems to have relatively few mutations in genes which cause changes in the proteins those genes code for.

--Joseph Levin, Rockefeller University