Selected Scientific Articles About Fibrolamellar

June, 2023 Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma

Science Advances

March, 2023 Defining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data

NPJ Precision Oncology

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January, 2023 Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DJAJB1-PRKACA

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Clinical Cancer Research

October, 2022 Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors


September, 2022 Targeting BCL-XL in Fibrolamellar Hepatocellular Carcinoma

Journal of Clinical Investigation Insight

August, 2022 β-catenin cancer–enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma

Hepatology Communications

May, 2022   Clinical and demographic predictors of survival for fibrolamellar carcinoma patients—A patient community, registry-based study

Hepatology Communications 

 October, 2021 Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening

Cancer Discovery

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February, 2021 DNAJB1-PRKACA in HEK293T Cells


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February, 2020 Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct
February, 2020 DNAJB1-PRKACA-positive metastatic fibrolamellar carcinoma with unknown primary in a pediatric patient
December, 2019 BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
November, 2019, DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma
May, 2019 An Acquired Scaffolding Function of the DNAJ-PKAc Fusion Contributes to Oncogenic Signaling in Fibrolamellar Carcinoma

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February, 2018 Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms
January, 2018 Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for FibrolamellarHepatocellular Carcinoma
December, 2017 Intracranial Metastasis in Fibrolamellar Hepatocellular Carcinoma
December, 2017 Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion
November, 2017 DNAJB1-PRKACA Fusion Kinase Interacts with β-catenin and the Liver Regenerative Response to Drive Fibrolamellar Hepatocellular Carcinoma
September, 2017 CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
September, 2017 Molecular Testing for the Clinical Diagnosis of Fibrolamellar Carcinoma
August, 2017 CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma
March, 2017 A Proposed Physiopathological Pathway to Hyperammonemic Encephalopathy in a Non-Cirrhotic Patient with Fibrolamellar Hepatocellular Carcinoma without Ornithine Transcarbamylase (OTC) Mutation
March, 2017 Environmental Exposures as a Risk Factor for Fibrolamellar Carcinoma
March, 2017 Comprehensive Analysis of the Cancer Genome Atlas Reveals a Unique Gene and Non-coding RNA Signature of Fibrolamellar Carcinoma
November, 2016: Liver transplantation for fibrolamellar hepatocellular carcinoma: A national perspective
October, 2016: Prognosis of Fibrolamellar Carcinoma Compared to Non-cirrhotic Conventional Heptocellular Carcinoma
February, 2016: Hepatobiliary and Pancreatic: Post-transplant recurrence of fibrolamellar hepatocellular carcinoma in lung and pancreas
Journal of Gastroenterology and Hepatology
January, 2016: Caroli’s Syndrome with Incidental Fibrolamellar Carcinoma on Liver Explant
Indian Journal of Pediatric Medicine
December 30, 2015: Hepatocellular Carcinoma, Fibrolamellar Variant: Diagnostic Pathologic Criteria and Molecular Pathology Update. A Primer
Nov 18, 2015: Hepatocellular Carcinoma in the Pediatric Population: A Population Based Clinical Outcomes Study Involving 257 Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1973-2011)
Hepatobiliary Surgery
November 3, 2015:  Transcriptomic characterization of fibrolamellar hepatocellular carcinoma
October — December, 2015: Fibrolamellar carcinoma versus scirrhous hepatocellular carcinoma : diagnostic usefulness of CD68
Acta gastro-enterological Belgica
October 6, 2015: Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells
October 5, 2015:  Synchronous Fibrolamellar Hepatocellular Carcinoma and Auricular Myxoma
September 2, 2015: Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features
August 11, 2015: FGFR1 and FGFR2 in Fibrolamellar Carcinoma
July- August 2015: Tumours and liver transplants
July 30, 2015: Post-transplant recurrence of fibrolamellar hepatocellular carcinoma in lung and pancreas
Journal of Gastroenterology and Hepatology
June, 2015: Treatment of Paraneoplastic Hyperammonemia in Fibrolamellar Hepatocellular Carcinoma With Oral Sodium Phenylbutyrate
Journal of Pain Symptom Management
April-June, 2015: Fibrolamellar hepatocellular carcinoma with extensive vascular thrombosis
Journal of Cancer Research and Theapeutics
March 31, 2015: Fibrolamellar hepatocellular carcinoma presenting as obstructive jaundice: uncommon presentation of a rare entity
Polish Journal of Radiology
March, 2015: Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases
Clinics (Sao Paulo)
February 26, 2015: Hepatocellular carcinoma with both fibrolamellar and classical components: an unusual morphological pattern
Case Reports in Pathology
February 24, 2015: Fibrolamellar hepatocellular carcinoma: a rare but distinct type of liver cancer
February 20, 2015: DNAJB1-PRKACA is specific for fibrolamellar carcinoma
Modern Pathology
January 20, 2015: The Genomic Landscape of Fibrolamellar Hepatocellular Carcinoma: Whole Genome Sequencing of Ten Patients
January, 2015: Prognostic Factors in Fibrolamellar Hepatocellular Carcinoma in Young People
Journal of Pediatric Surgery
December 31, 2014: Unique Genomic Profile of Fibrolamellar Hepatocellular Carcinoma
December 31, 2014: Central Element in Liver Masses, Helpful or Pitfall?
Abdominal Imaging
December, 2014: Advances in Fibrolamellar Hepatocellular Carcinoma: a Review
December, 2014: Surgical Treatment of Fibrolamellar Hepatocellular Carcinoma: an Underestimated Malignant Tumor?
Hepatobiliary Pancreatic Disease International
August 13, 2014: Genomic analysis of fibrolamellar hepatocellular carcinoma
Abstract in Hum Mol Genet.
June 27, 2014: Downstaging and resection after neoadjuvant therapy for fibrolamellar hepatocellular carcinoma
Abstract in World J Gastrointest Surg
June 13, 2014: mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma
Abstract in Modern Pathology
February 28, 2014: Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma
Abstract in Science magazine
July, 2013: Radiotherapy for Metastatic Fibrolamellar Hepatocellular Carcinoma
July 2013: Surgical Resection of Ruptured Fibrolamellar Hepatocellular Carcinoma
Fibrolamellar variant of hepatocellular carcinoma
Author’s abstract
October 31, 2012: A Systematic Review: Treatment and Prognosis of Patients with Fibrolamellar Hepatocellular Carcinoma
Plain English summary
October 2012: Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection
Abstract in Cancer magazine
October 2012 Clinicopathologic Features and Prognosis of Young Patients With Hepatocellular Carcinoma in a Large German Cohort
Authors’ abstract
October 2012: Focal hepatic lesions in Gd-EOB-DTPA enhanced MRI: The Atlas
Abstract in Insights Imaging
September 25, 2012: Cytologic features of fibrolamellar carcinoma with mucin production: A rare variant of combined hepatocellular-cholangiocarcinoma.
Abstract in Diagn Cytopathol
September 12, 2012: Long-term results of liver resection for hepatocellular carcinoma in noncirrhotic liver
Sept 10, 2012: Aggressive surgical management of recurrent lymph node and pancreatic head metastases of resected fibrolamellar hepatocellular carcinoma: a case report
Article in J of the Pancreas
Plain English summary
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August 8, 2012: Molecular Characteristics of Fibrolamellar Hepatocellular Carcinoma
Authors’ abstract
June 2012: Liver tumours, toxic hepatitis, intestinal failure-associated liver disease in children
Authors’ abstract
June 2012: Fibrolamellar hepatocellular carcinoma with cardiac spread causing severe inferior vena cava obstruction in a 9-year-old child
Abstract in Pediatr Cardio
March 2012: Fibrolamellar hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus, and pulmonary emboli
Reference to article in Hepatology
February 2012: A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
Abstract in J Bioenerg Bioememb
February 2012: Fibrolamellar hepatocellular carcinoma metastatic to the ovary
Reference to article in J Obstet Gynaecol
Jan 23, 2012: Loss of the orphan nuclear receptor SHP is more pronounced in fibrolamellar carcinoma than in typical hepatocellular carcinoma
Free copy of article in PLoS One
Jan-Feb 2012: A large fibrolamellar hepatocellular carcinoma in a 17-year-old male body builder
Abstract in Biotechnol Appl BIochem
January 2012: GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation
Abstract in J Hepatol
January 2012: Prolonged Complete Response after GEMOX Chemotherapy in a Patient with Advanced Fibrolamellar Hepatocellular Carcinoma
Free copy
Plain English summary